| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering
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| Autores: |
Senni, Karim
Pereira, Jessica
Gueniche, Farida
Delbarre-ladrat, Christine
Sinquin, Corinne
Ratiskol, Jacqueline
Godeau, Gaston
Fischer, Anne-marie
Helley, Dominique
Colliec-jouault, Sylvia
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| Data: |
2011-09
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| Ano: |
2011
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| Palavras-chave: |
Marine bacteria
Marine algae
Exopolysaccharides
Sulfated polysaccharides
Structure
Chemical modification
Biological activity
Blue biotechnology
Cell therapy
Tissue engineering
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| Resumo: |
The therapeutic potential of natural bioactive compounds such as polysaccharides, especially glycosaminoglycans, is now well documented, and this activity combined with natural biodiversity will allow the development of a new generation of therapeutics. Advances in our understanding of the biosynthesis, structure and function of complex glycans from mammalian origin have shown the crucial role of this class of molecules to modulate disease processes and the importance of a deeper knowledge of structure-activity relationships. Marine environment offers a tremendous biodiversity and original polysaccharides have been discovered presenting a great chemical diversity that is largely species specific. The study of the biological properties of the polysaccharides from marine eukaryotes and marine prokaryotes revealed that the polysaccharides from the marine environment could provide a valid alternative to traditional polysaccharides such as glycosaminoglycans. Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00048/15894/13316.pdf
DOI:10.3390/md9091664
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| Editor: |
Mdpi Ag
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| Relação: |
http://archimer.ifremer.fr/doc/00048/15894/
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| Formato: |
application/pdf
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| Fonte: |
Marine Drugs (1660-3397) (Mdpi Ag), 2011-09 , Vol. 9 , N. 9 , P. 1664-1681
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| Direitos: |
2011 MDPI
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